Fig 2: SINETs express high levels of OR51E1 and OMP proteins and nonanoic acid increases the metabolic activity in primary cultured SI-NET cells. (A) Representative examples and distribution of protein expression score of OR51E1 and OMP in SI-NETs evaluated by IHC in a TMA. (B) Effect of OR51E1 agonist nonanoic acid on metabolic activity in primary cultivated SI-NET cells from 5 patients (control = DMSO vehicle), n is the number of replicates and the graph depicts a symbol at the mean and bars depict range (C) Effect of non-agonist 1-nonanol on metabolic activity in primary cultivated SI-NET cells from 5 patients (control = DMSO vehicle), n is the number of replicates and the graph depicts a symbol at the mean and bars depict range. (D) Pooled results (all patients and replicates), symbol at mean and bars depict standard deviation, **** = p < 0,0001, *=p < 0,05